HPA Backs AI-Native Cardiovascular Platform Revolutionizing Heart Care Delivery
HPA is pleased to announce its participation in the oversubscribed $16.2 million Series A financing round for Karoo Health, the cardiovascular technology company building the operating system for cardiac care. The round was co-led by 7wire Ventures and Allumia Ventures, with additional participation from HPA, First Trust Capital Partners, and SpringRock Ventures. As part of the financing, Lee Shapiro, Managing Partner at 7wire Ventures, and Jeff Stolte, Managing Partner at Allumia Ventures, will join Karoo’s Board of Directors.
Karoo is addressing the single largest driver of healthcare costs in the United States: cardiovascular disease. Cardiac care today remains fractured across clinical systems, claims data, pharmacy records, and care teams—fragmentation that contributes to delayed intervention, inconsistent chronic disease management, and avoidable hospital utilization, procedures, and testing. Karoo’s AI-native platform connects payers, providers, and patients through a unified data and workflow layer, enabling earlier risk detection, coordinated care delivery, improved outcomes, and lower total cost of care.
“We’re at a seminal moment in our country’s fight against cardiovascular disease,” said Karoo Health CEO and Cofounder Ian Koons. “We intend to use this capital to take another major step toward becoming the solution that enables every American to access earlier, more coordinated, and more effective cardiovascular care.”
HPA has a strong reputation for backing transformative technologies led by exceptional teams targeting massive, underserved markets. Karoo Health fits this criteria perfectly:
- Massive Market Opportunity: Cardiovascular disease remains the leading driver of healthcare costs in the United States, and the shift toward value-based cardiac care is accelerating. Karoo sits at the center of this transition, positioned to capture a large and attractive market where payers and providers urgently need solutions that reduce avoidable utilization and cost.
- AI-Native Advantage: Karoo’s platform moves beyond point solutions, combining predictive models, clinical signal detection, and care coordination infrastructure into a true operating system for cardiovascular care—a fundamental shift in how cardiac patients are identified, monitored, and managed.
- Early Validation at Scale: Karoo today supports a network of more than 600 cardiology providers across 11 states and operates programs with leading national and regional health plans, with additional launches planned later this year. In deployed programs, independent analyses reported reductions of more than 40% in emergency department visits and inpatient admissions, and early results show an approximately 9% reduction in total cost of care across attributed populations.
“Karoo’s ability to rapidly secure major health-plan partners, deliver notable cost savings, and maintain strong provider alignment makes this a particularly compelling opportunity in a large and attractive cardiovascular market,” said George Gjermano, HPA Deal Lead for Karoo.
With this new funding, Karoo will continue advancing its AI-native cardiovascular platform, including continued development of predictive models, clinical signal detection capabilities, and care coordination infrastructure, while expanding its engineering and clinical teams and scaling deployments with payer and provider partners nationwide.
On behalf of HPA, we congratulate Ian and the entire Karoo Health team on this important milestone and are thrilled to support the company’s mission to free people from the pain of cardiovascular disease.
Special thanks to HPA Deal Lead George Gjermano, HPA Partner Michael Sachaj and HPA Senior Associate Michelle Rogoff, who were instrumental in closing the round and will be the HPA team supporting Karoo in its next stage of growth.
Read more about it here: Press Release